Human Brain Project research on Alzheimer’s
To mark World Alzheimer’s Month, we curated a selection of news items, publications, and partnering projects that highlight the Human Brain Project's commitment to dementia research.
News items
Brain simulation augments machine-learning–based classification of dementia
Brain simulation methods can be used to improve the classification of dementia and could in the future constitute a new diagnostic tool to help direct patients towards the right treatment.
New insights on brain region implicated in aging and cognitive decline
Does shrinking of the angular gyrus in the brain lead to cognitive decline as we get older? A new study by Human Brain Project scientists in Germany has revealed a clearer picture.
Dutch HBP researchers contribute to uncovering neuronal diversity in the human brain
Researchers show that evolutionary expansion of a part of the human brain that is responsible for cognitive function involves cell diversification–with possible consequences to our susceptibility to Alzheimer's.
HBP scientist Svenja Caspers uses big data to better understand why brains vary so much in ageing
In order to better understand why individual brains vary so much, scientists at the Human Brain Project are using brain models and simulations.
Partnering projects
The MILEDI (Multiscale Modelling of Impaired LEarning in Alzheimer’s Disease and Innovative Treatments) project aims at developing a new multi-scale (integrated molecular, cellular and network levels) data-driven in silico model of the hippocampal CA1 region under Alzheimer's disease conditions.
AI-Mind designs intelligent digital tools for screening of brain connectivity and dementia risk estimation in people affected by mild cognitive impairment.
The goal of TVB-CD is to understand neurodegenerative disorders like Alzheimer's from the perspective of dynamical network function.
Brain Matters
Brain Matters #10 - Special episode on Alzheimer's - “How the Human Brain Project enables clinical research for dementia”
The session was moderated by Petra Ritter, Head of the Brain Simulation Section at Charité Berlin, and featured the following HBP researchers:
- Leon Stefanovski (Charité Berlin) who presented 'Brain simulation to improve classification in Alzheimer’s dementia and in silico drug testing'
- Jil Mona Meier (Charité Berlin) who presented 'In silico deep brain stimulation to improve patient outcomes in Parkinson’s dementia'
- Michael Schirner (Charité Berlin) who presented 'Multiscale brain network modeling to infer principles of cognitive brain function'
