HBP’s Florent Gaillard reports back from the HBP’s 5th School, a week of deep, hands-on learning in the Austrian alps.
In late November, 29 students and 13 senior scientists gathered in Obergurgl, Austria, for the 5th HBP School on Brain Disease Neuroscience. This winter school delivered a unique overview of brain disease modeling across different pathologies, methods and levels, with a focus on the clinical impact of neuroscience. The School also emphasised student projects, interactions, participation and networking, stimulating bonds and synergies in an enthusiastic atmosphere. The School is an initiative of the Education Programme of the Human Brain Project (HBP) and in collaboration with The Medical Informatics Platform (MIP, HBP Subproject 8).
A broad approach to neuroscience
The goal of the school was to give a broad view of the different approaches to brain-related diseases and to get the active involvement of the participants. The primary focus was on dementia and Alzheimer’s disease, epilepsy and strokes. These were investigated from the micro-circuit scale up to the phenotype and cognitive level, using EEG, MRI, Scores and other techniques.
The week in a nutshell
- 13 lecturers – senior scientists from 8 countries
- 29 students, from 15 countries
- 12 lectures
- 3 hands-on sessions
- 6 projects over 5 days
- 29 lightning talks and posters
- More than 35 hours of supervised work
- Social events (skiing, snowshoe hike, evening beers)
“Meeting all these amazing and bright people really inspired me to set myself some bigger goals and also reminded me, how crucial collaboration is in the field of neuroscience and medicine in general. It really was a boost of fresh ideas and broad perspectives” - medical student Domantė Sakalauskaitė
Today’s program is all about #epilepsy: Alain Destexhe (@CNRS) speaks about the role of excitation-inhibition interplay in the modelling of epileptic seizures. #5thHBPSchool #futuremedicine @HBPmedical pic.twitter.com/rBq9HCGMFY— HBP Education (@HBP_Education) November 29, 2017
Now at the #5thHBPSchool: Ana Solodkin (@UCIrvineHealth) on therapeutic approaches for stroke and Alzheimer using large-scale brain network models. #PrecisionMedicine @thevirtualbrain pic.twitter.com/IhjUHxupwY— HBP Education (@HBP_Education) November 28, 2017
"The HBP school brings together faculty and scientists in training interested in innovative multi-scale modeling approaches to understand the brain. One of the most important consequences of this design resulting from the collective interactions between participants, is the development of richer and novel perspectives on the meaning of precision medicine." - Ana Solodkin, The Virtual Brain
"The scientific programme was excellent, the location magical and the group of attendees, speakers and organisers was fantastic. I’d recommend any young researcher who wants to improve their understanding of current neuroscience research, gain new skills and meet other young scientists from across Europe to attend an HBP School!" - Danka Jandric
Above left, Alain Destexhe from EITN presenting about epilepsy through spikes observation at micro-circuit level, and above right Ana Solodkin from Irvine University in California lecturing on AD on large-scale brain network.
“This winter school has assembled two communities that normally are separated: the community of clinicians and specialists of brain diseases, with theoreticians and computational neuroscientists interested in simulating the mechanisms of disease, from simple neural circuits to large-scale brain networks,” explained Alain Destexhe from CNRS, director of the European Institute for Theoretical Neuroscience in Paris, scientific committee member of the 5th HBP School and involved lecturer / mentor.
In the first talk this morning at the #5thHBPSchool, Peter Taylor (@UniofNewcastle) discusses recent studies on structural & functional connectivity-based macroscopic modelling in #epilepsy. @HBPmedical @HumanBrainProj pic.twitter.com/mp6CVB08IL— HBP Education (@HBP_Education) November 29, 2017
#5thHBPSchool Mario Rosanova from Milano University Lecturing Pathological sleep-like activity in brain-injured patients. @HBP_Education @HBPmedical #EEG #brainscience #braininjury pic.twitter.com/te2CQ56bBR— HBP MedicalPlatform (@HBPmedical) December 1, 2017
Above left, Peter Taylor from Newcastle University in the UK talks macroscopic modelling and above right Mario Rosanova from Milano University talks brain injuries.
A deep dive into a topic
The 5th HBP School also introduced week-long project sessions. Six subjects were chosen to be treated in greater depth during week-long afternoon sessions. Each afternoon, participants broke into small groups to explore these topics under the mentoring of the relevant lecturers. Using computational tools and models, data and biological biomarkers, the participants were able to come up with impressive results and conclusions on subjects such as disease progression prediction, seizure transition models or brain dynamics after certain types of lesion. On the last day, each group presented their outcomes in plenary talks of 45 minutes each.
The last day at the #5thHBPSchool was dedicated to our young researchers, who presented the results of their group projects. Very impressive! #braindisease #neuroscience #futuremedicine pic.twitter.com/iX7ykMxy6m— HBP Education (@HBP_Education) December 2, 2017
Loved learning to use @thevirtualbrain to model network dynamics following stroke with these guys! Many thanks to our amazing tutors, @AnaSolodkin , Andreas Spiegler and Spase Petkoski. #5thHBPSchool pic.twitter.com/mUAwNtxUTE— Danka Jandric (@dankajandric) December 2, 2017
Above, left and right: Each group of students presented their conclusions in a 45 minute presentation in plenary sessions. A good exercise also to structure results and to work on public speaking skills.
The aim of this kind of project sessions was to push the students to be actors, to work in teams and to interact more closely with senior scientists. They also got a much deeper look into concrete work and methods, thanks to the involvement of the tutors throughout the week.
Posters, lightning talks and networking
Lectures, hands-on, group projects, is that all? No, it was not: During the week, each participant also presented their current or previous work during a lightning talk and a related poster exhibit, which opened the door to great interactions among the participants and with the lecturers and senior scientists.
Alois Saria, leader of the HBP Education Programme, emphasized: “That is precisely what HBP Schools are about: bringing up valuable quality lectures and content from speakers and mentors of various fields, stimulating the interactions between students and senior scientists, proposing a unique ex-cathedra program over a week based on the sharing of experience.”
“The interactions that were started in this school will undoubtedly lead to useful collaborations to better understand brain diseases,” Destexhe added.
This year, the Best Poster prizes all went to… women scientists! Ada Johanne Ellingsrud from Oslo, Domantė Sakalauskaitė from Vilnius and Anja Kaja Ries from Munich.
A privileged environment
The School took place at the Obergurgl University Center of the University of Innsbruck, Austria. These premises also contributed to the success of the school, with lectures, breakout rooms, accommodation, and restaurant all on site. This strengthened the bonds, and helped stimulate the rich and essential conversations that made the week so successful.
The venue is located on the ski slopes, which was an incredible opportunity to use the afternoon breaks for a little bit of fun exercise, whether it was on skis or in a guided snowshoe hike organised by the Education team. Following a complete week of advanced neuroscience can be demanding on neurons but nothing a good breath of mountain air can’t fix!