Human Brain Project research on Stroke
To mark World Stroke Day, we’ve curated a selection of news items, publications, and partnering projects that highlight the Human Brain Project's commitment to stroke research.
News item
HBP researchers unveil importance of subcortical-cortical dynamics in stroke
A new study by researchers of the Human Brain Project suggests that an alteration of the normal coordination between subcortical and cortical regions of the brain can be an important mechanism explaining neurological dysfunction after suffering a stroke. The researchers, who have published their results in Nature Communications, looked into spontaneous patterns of communications as an indicator of stroke-related damage and disruption of function.
Publications
Cortical propagation tracks functional recovery after stroke
Gloria Cecchini, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Curzio Checcucci, Emilia Conti, Ihusan Adam, Duccio Fanelli, Roberto Livi, Francesco Saverio Pavone, Thomas Kreuz
Read the full paper in PLOS Computational Biology
Cortical reorganization after motor stroke: A pilot study on differences between the upper and lower limbs
Ellen Binder, Martha Leimbach, Eva-Maria Pool, Lukas J. Volz, Simon B. Eickhoff, Gereon R. Fink, Christian Grefkes
Read the full paper in Human Brain Mapping
Early motor network connectivity after stroke: An interplay of general reorganization and state-specific compensation
Theresa Paul, Lukas Hensel, Anne K. Rehme, Caroline Tscherpel, Simon B. Eickhoff, Gereon R. Fink, Christian Grefkes, Lukas J. Volz
Read the full paper in Human Brain Mapping
Subcortical-cortical dynamical states of the human brain and their breakdown in stroke
Chiara Favaretto, Michele Allegra, Gustavo Deco, Nicholas V. Metcalf, Joseph C. Griffis, Gordon L. Shulman, Andrea Brovelli & Maurizio Corbetta
Read the full paper in Nature Communications
Partnering projects
The RGS@HOME project advances science grounded neurorehabilitation methods, which can be used by patients during the full patient journey. RGS targets motor and cognitive recovery after stroke and is based on brain theory, delivering rehabilitation and diagnostics using Al, virtual reality, and cloud computing.
The Brainsynch-Hit project aimed to develop and test methods for the analysis of directional interactions among brain regions in resting state and task-evoked fMRI data in healthy controls and stroke damaged individuals, and to develop a computational model of an injured brain that replicates both the empirically measured patterns of connectivity abnormalities and behavioral deficits.
Webinar
Diversity in Brain Research: does it matter?
In this webinar on 18 May 2022, the Human Brain Project encouraged scientists to consider sex, gender and additional diversity factors in neuroscience and related fields: because biology, social factors and culture play an important role in shaping the brain.
Sanne Peters – who won the Diversity in Research Paper Award - presented her paper “Sex differences in the association between major risk factors and the risk of stroke in the UK Biobank cohort study.”
