Paolo Carloni is the head of the Institute for Advanced Simulation – Computational Biomedicine (IAS-5/INM-9) at Forschungszentrum Jülich. He is a molecular modelling specialist and carries out research in the HBP’s areas of simulation and drug design. His team’s supercomputing-powered simulations provide insight on the workings of signaling molecules in the brain and have led to patented drug candidates for neurodegenerative diseases. His institute is involved in a HBP project addressing Covid-19-induced brain fog using computer-designed molecules that target brain inflammation.