EBRAINS Infrastructure Training on

MODEL VALIDATION

4–7 May 2021 | Virtual Event

 

Preliminary Programme_EBRAINS_Model_Validation.pdf 1.8 MB

 

 

 

Background:

A major shortcoming in computational neuroscience in the absence of a well-defined system for the validation and comparison of models. This impedes progress, with modellers often working in isolation from experimentalists, and leads to unecessary difficulty in comparing published models to each other or to new data. The process of model validation is typically manual, qualitative, and limited in the number of properties tested. Explicitly quantifying the differences between simulation and experimental results, decoupling test definitions from individual models, and automating the processes of finding and running tests, can greatly increase the productivity of the simulation-validation cycle, thereby reinforcing the scientific method.

The EBRAINS Model Validation Framework provides web-based tools for working with computational models, and the validation of such models against experimental data with a systematic, unbiased and reproducible approach. It consists of a REST web service and two clients: the Model Catalog collaboratory app and a Python client. Underlying metadata are stored in the Knowledge Graph, thereby coupling it with other EBRAINS workflows. The framework broadly allows users to (i) create, edit, search and view metadata about models and validation tests, and (ii) register, search, view and compare the results of validations run on models.

 

 

This training will guide modellers and experimentalists in model validation (comparing simulation results to experimental data) using the EBRAINS Model Validation Framework.

Participants will learn how to:

  • develop model-agnostic validation tests
  • adapt existing models so they can be more easily validated
  • use the EBRAINS model and test catalogue
  • register, search, view and compare the results of validation tests

The training takes place over four days, with two days of presentations and hands-on demos, followed by two days of participants working on their own validation projects with the assistance of the tutors.

 

PROGRAMME   Up-to-date online version of the Programme!

 

The training is open to all interested researchers working with brain models. The hands-on sessions and project work (last two days) would be undertaken using Python programming language. Some familiarity with Python would be useful, but not essential.

For this 2nd part of the training, you are welcome to send us a short abstract, describing your model.

Abstracts should include:

  • A short description of your model
  • Simulators/tools used for developing and simulating models
  • Overview of validation(s) you wish to implement during the training (specify at least one validation test), along with target (experimental) reference data
  • If you have already some questions or comments, you are welcome to mention them
  • If your model is already published, please include references at the end of the abstract

Please send your abstract latest until 20 April 2021, 5pm (CET) to training-support@humanbrainproject.eu.

 

REGISTRATION

To register to the event, an EBRAINS account is needed. With the EBRAINS account, you will get access to the tools and services trained in this event. Please create your account at https://ebrains.eu/register (free of charge). After your EBRAINS account is created, you can register to this event.
 
REGISTRATION       Registration will close 30. April 2021!
 
 

 

CONFIRMED SPEAKERS

Dr. Shailesh Appukuttan is a postdoctoral researcher in the Department of Integrative and Computational Neuroscience of the Paris-Saclay Institute of Neuroscience (CNRS, Université Paris-Saclay), France, with the Neuroinformatics research group. He is interested in the application of computational techniques to further biological research. As part of the Human Brain Project (HBP), his work involves the design and development of a model validation framework for neuroscience, and its integration into existing model development workflows, along with development of other related scientific tools.
Personal webpage: http://shailesh-appukuttan.scienceontheweb.net/

Dr. Andrew Davison is a senior research scientist in the Department of Integrative and Computational Neuroscience of the Paris-Saclay Institute of Neuroscience (CNRS, Université Paris-Saclay), France, where he leads the Neuroinformatics research group. His research interests focus on biologically detailed modelling of neuronal networks (particularly the mammalian visual system), and on developing tools to improve the reliability, reproducibility, and efficiency of biologically realistic simulations.

Prof. Rick Gerkin researches the design and validation of neural models from single neurons to human psychophysics. As the lead developer of SciUnit he is interested in a Pythonic approach to introducing test-driven development into the modeling process. Other efforts include the curation of diverse datasets from which such model validation tests can be constructed. He is also the Data Science Core lead on the "Cracking the Olfactory Code" consortium sponsored by US NIH, integrating physiological, optical, genomic, and behavioral data into a unified analysis and discovery framework.

Sára Sáray is a doctoral candidate in the Department of Cerebral Cortex Research of the Institute of Experimental Medicine and the Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Hungary. She is interested in the systematic construction and validation of detailed models of hippocampal neurons based on electrophysiological data.

Her research interests include the computational modeling of dendritic integration in hippocampal pyramidal cells.

 

 

 

 

SCIENTIFIC CHAIRS
Shailesh Appukuttan | CNRS, France
Andrew Davison | CNRS, France
 
ORGANISER
EBRAINS Infrastructure Training Support | Heidelberg University, Germany
 
CONTACT
 
 
TOOL, DOCS, AND TUTORIAL:
a) Requiers a free EBRAINS Account:
  1. Model Catalog (Validation Framework) App
    https://model-catalog.brainsimulation.eu/
b) Free to access:
  1. Model Catalog (Validation Framework) App - Docs:
    https://model-catalog.brainsimulation.eu/docs/
  2. Validation Framework REST APIs:
    https://validation-v2.brainsimulation.eu/docs
  3. Validation Framework Python Client Docs:
    https://hbp-validation-client.readthedocs.io/
  4. SciUnit Tutorials:
    https://sciunit.readthedocs.io/en/latest/quick_tutorial.html
  5. HippoUnit Repository:
    https://github.com/KaliLab/hippounit
  6. HippoUnit Documentation:
    https://hippounit.readthedocs.io/

 

FAQs & all you need to know

Registration is mandatory and is open until 30 April 2021.
Please make sure to register with your institutional email address.
Attendance is open to anyone and free of charge.

The link to our virtual conference platform as well as the online credentials will be sent out to all registered participants a few days prior to the event. 

To make this virtual training an interactive experience, it is important that you have access to a stable internet connection, good audio (with microphone) and ideally (not mandatory) a webcam for video communication.

Also, to have the full conference experience it is important that you have installed the Zoom Desktop Client application (v5.3.0 or higher) and that you access the conference platform via the latest version of Google Chrome.

If you have any questions about the event, please contact us at training-support@humanbrainproject.eu

All times in the programme schedule are UTC+2 = CEST.

To prevent missed sessions, we recommend to use a time zone converter in advance.