THE FUTURE OF MEDICAL DATA SHARING
IN CLINICAL NEUROSCIENCES

EAN-EBRAINS Joint Workshop


9–11 December 2021 | Virtual Event

On-site part has been cancelled due to Covid-19 developments

Download Final Programme 1.6 MB

 


FAQs & all you need to know
 

Registration is free but mandatory.

Attendance is open to anyone.
Please make sure to register with your institutional email address.

The link to our virtual conference platform as well as the online credentials will be sent out to all registered participants a few days prior to the event. 

To make this virtual event an interactive experience, it is important that you have access to a stable internet connection, good audio (with microphone) and ideally (not mandatory) a webcam for video communication.

Also, to have the full conference experience it is important that you have installed the Zoom Desktop Client application (v5.3.0 or higher) and that you access the conference platform via the latest version of Google Chrome

If you have any questions about the event, please contact us at 
workshop.edu@humanbrainproject.eu.

All times in the programme schedule are UTC+1/GMT+1= CET.

To prevent missed sessions, we recommend to use a time zone converter in advance. 

 

Find more about

EAN: https://www.ean.org/

MIP: https://ebrains.eu/service/medical-informatics-platform/

 

Data sharing stimulates science in all scientific disciplines, including the Clinical Neurosciences. Promotion of data sharing and the implementation of standardized harmonization rules among a global research community reduces the burden of unexploited research and plays a critical role in mitigating the problems of reduced sample sizes. Today, medical and research activities in clinical neuroscience produces a massive amount of data that could leverage our knowledge and understanding of brain diseases. Unfortunately, despite growing incentives for open data, most of it remains currently locked in hospitals or labs, either for regulatory or cultural reasons.

The Medical Informatics Platform (MIP) was developed in the framework of the Human Brain Project (HBP) as an innovative tool to investigate, compare and analyse large patient datasets distributed across centers without requiring the data to be transferred and stored outside their site of origin. The platform is integrated in EBRAINS, the sustainable European Research Infrastructure for brain-related research and legacy of the HBP.

Recently, the HBP has started a pilot project with the European Academy of Neurology (EAN) with the idea to use the MIP to promote clinical data sharing using a federated approach. EAN is the primary scientific and educational European organisation in the field of Clinical Neurosciences, including more than 45,000 members, as well as 47 European National Societies. EAN is committed to scientific progress and aims to keep Europe at the forefront of neurological research and to maintain its position as one of the world’s scientific hotpots in neurology.

The HBP and EBRAINS together with the EAN invited the entire scientific community to join this workshop on the Future of Medical Data Sharing in Clinical Neurosciences. This event aimed at exposing and openly discussing all issues and challenges associated with data sharing in Europe, from ethics to data safety and privacy, including those specific to data federation, such as the development and validation of federated algorithms. A platform to disclose the preliminary results of these use-cases, four brainstorming sessions involving EAN Scientific Panels, demonstrations and a hands-on session, which highlighted important aspects and issues of medical data sharing and offered participants the possibility to understand how to use the MIP for their own applications, were proposed.

 

 

FINAL PROGRAMME

*The HBP and the EAN Scientific Committee have co-developed this programme.

The time zone of the event is CET (UTC/GMT+1).

Download Final Programme 1.6 MB

 

13:30


REGISTRATION

14:00


PLENARY SESSIONS:
 

14:00


Introduction
Thomas Berger | Medical University Vienna & Philippe Ryvlin Centre hospitalier universitaire vaudois

14:15


HBP: An overview
Katrin Amunts Forschungszentrum Jülich

14:45


EBRAINS: The future of HBP
Paweł Świeboda EBRAINS AISBL

15:15


EAN: Achievements and Ambitions
Paul Boon University of Ghent

15:45 COFFEE BREAK
16:15


EHDS: The future of data sharing in Europe
Ioana-Maria Gligor European Comission - European Reference Networks and Digital Health

16:45


MIP: Why federating data in Medicine
Philippe Ryvlin Centre hospitalier universitaire vaudois

17:15


EAN: Why sharing data in clinical neurosciences
Thomas Berger Medical University Vienna

17:45 END OF SESSION
  PARALLEL SESSIONS
 
FEDERATION USE CASES
             
FEDERATION CHALLENGES

            

8:30

            


Parallel session 1: Dementia
Chairs: Jean-François Demonet 
             & Gilles Allali Centre hospitalier universitaire vaudois 
Parallel session 2: Ethics
Chair: Bernd Stahl De Montfort University
08:30
The spectrum of data sharing in dementia
P.J. Visser | Amsterdam University Medical Centers
             

            

 

            

09:00

            


            The MIP federation in dementia
            Mélanie Leroy | Université de Lille

            

How to make data public
Maaike van Swieten & Jan Bjaalie | University of Oslo
09:30 EAN scientific panel on dementia
Kristian Steen Frederiksen | Danish Dementia Research Centre, Rigshospitalet Copenhagen University Hospital, Memory Disorders Research Unit

Ethics requirements for MIP usage
Erika Borcel | Centre hospitalier universitaire vaudois
             
10:00 COFFEE BREAK COFFEE BREAK
  10:30    Parallel session 3: Traumatic Brain Injury
Chairs: Matthew Abrams Karolinska Institutet & Stefano Finazzi Mario Negri Institute for Pharmacological Research IRCCS

            Parallel session 4: Data safety
Chair: Oksana Kulyk  IT University of Copenhagen
             
10:30

            
 EAN scientific panel on neurotraumatology
 Dafin Muresanu Foundation of the Society for the Study of Neuroprotection and Neuroplasticity (SSNN)

The challenge of protecting hospital data
Franck Calcavecchia Hopitaux Universitaires de Genève
11:00

 

The MIP federation in TBI
Stefano Finazzi Mario Negri Institute for Pharmacological Research IRCCS
             

            

Data safety in FENIX Infrastructure
Stefano Gorini & Alex Upton CSCS
                         

11:30  

CAPTAIN Trials (I and III) - a new horizon in TBI

 Dafin Muresanu Foundation of the Society for the Study of Neuroprotection and Neuroplasticity (SSNN) 
 

      

How to secure MIP networks across hospitals
Emrah Kavun Centre hospitalier universitaire vaudois
             

12:00 LUNCH BREAK LUNCH BREAK
13:30 Parallel session 5: Stroke
Chair: Anna Bersano | Fondazione IRCCS Istituto Carlo Besta & Charlotte Cordonnier | Université de Lille
Parallel session 6: Data privacy
Chairs: Jean Louis Raisaro Centre hospitalier universitaire vaudois
& Yannis Ioannidis University of Athens, Athena Research Center
13:30
The impact of data sharing in stroke
Valeria Caso | University of Perugia
             
Introduction of state-of-art of methods for ensuring data privacy
Barbara Carminati | Università degli studi dell'Insubria
13:55

            

The spectrum of national and European stroke registries
Georgios Tsivgoulis | National and Kapodistrian University of Athens
 

Risk-based data anonymization for medical research
Fabian Prasser | Charité Berlin
14:20 Why federating stroke registries
 Maurizio Leone | IRCCS Casa Sollievo della Sofferenza

Differential privacy
Minos Garofalakis | Technical University of Crete
             
14:45 EAN scientific panel on stroke
Anna Bersano | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

The present and future model of MIP data privacy
 Yannis Ioannidis | University of Athens, Athena Research Center
             
15:15 COFFEE BREAK COFFEE BREAK
15:45 Parallel session 7: Epilepsy
            Chairs: Reetta Kalviainen | Kuopio University Hospital  & Tim von Oertzen Kepler Universitätsklinikum

            Parallel session 8: Federated analytics
            Chairs: Jan Bjaalie | University of Oslo  & Yannis Ioannidis | University of Athens, Athena Research Center
             
15:45
Data sharing in epilepsy
Helen Cross | University College London
             
What is federated analysis
Yannis Ioannidis | University of Athens, Athena Research Center
16:15 The MIP federation in epilepsy
 Philippe Ryvlin | Centre hospitalier universitaire vaudois

How to build and validate a federated algorithm
Jason Sakellariou University of Athens
             
16:45 EAN scientific panel on epilepsy
Tim von Oertzen | Kepler Universitätsklinikum

            


The MIP federated analytics
Giorgos Papanikos | National and Kapodistrian University of Athens
             

            

17:15 Parallel session 9: Other/future use-cases
Chairs: Thomas Berger Medical University Vienna & Arseny Sokolov Centre hospitalier universitaire vaudois
Parallel session 10: Ontologies and knowledge graph
Chairs: Jan Bjaalie  | University of Oslo
             & Yannis Ioannidis University of Athens, Athena RC
17:15


European Database on Narcolepsy and related hypersomnia
            Yves Dauvilliers | University of Montpellier & Ramin Khatami Klinik Barmelweid             

            

Ontologies for clinical neurosciences
            Martin Hofmann-Apitius | University of Bonn/Fraunhofer-Institut für Algorithmen und Wissenschaftliches Rechnen SCAI
 
17:45
Neurorehabilitation
Letizia Leocani | IRCCS Ospedale San Raffaele
             
The power of EBRAINS Knowledge Graph
Jan Bjaalie | University of Oslo
18:15 NeuroCOVID
Elena Moro | Grenoble Alpes University

Using knowledge graph in hospitals
Christophe Gaudet-Blavignac | University of Geneva
             
18:45 END OF SESSION END OF SESSION
PARALLEL SESSIONS

 

Brainstorming from EAN scientific panels on data sharing
- 90 min each parallel session

(This session is open to EAN scientific panel members and upon invitation)

MIP hands-on sessions
9:00–10:30
Group 1
Chair: Maurizio Leone | Mario Negri Institute for Pharmacological Research
 
09:00  MIP Installation Erika Borcel | Centre hospitalier universitaire vaudois 

 

  • Administrative and technical steps towards MIP Installation


Neuroepidemiology
Ettore Beghi | Mario Negri Institute for Pharmacological Research

Pain
Martin Rakusa | University Medical Centre Maribor

Musle & NMJ disorders
Maria Judit Molnar | Semmelweis University Medical School

Movement disorders
Angelo Antonini | University of Padua

Neurogenetics
Sylvia Boesch Medical University Innsbruck

 


Group 2
Chair: Eavan McGovern Beaumont Hospital & Mara Rocca IRCCS Ospedale San Raffaele &
09:20 MIP Data Governance and Data preparation
Laith Abu-Nawwas  Centre hospitalier universitaire vaudois
 
  • Data governance principle
  • Delineating and implementing a data model in the MIP
  • Harmonizing a dataset according to the data model
  • Integrating anonymized data into the MIP


Child Neurology
Sarah Buerki | University Children‘s Hospital Zurich

Neurocritical care
Serefnur Ozturk | Selçuk University

Coma & Disorders of consciousness
Rita Formanisao | Fondazione Santa Lucia

Clinical Neurophysiology
Hatice Tankisi | Aarhus University Hospital

Neuroophthalmology & -otology
Nese Celebisoy Ege University

 

 

Group 3
Chair: Romana Höftberger Medical University Vienna
 
10:00 Extracting regional brain volumes from the MIP MRI pipeline
Laith Abu-Nawwas & Carolina Ciumas  Centre hospitalier universitaire vaudois


Multiple Sclerosis & Neuroimmunology
Celia Oreja-Guevara Hospital Clínico San Carlos de Madrid

Infectious diseases
Pille Taba University of Tartu

Neurooncology
Anette Storstein Haukeland University Hospital

Neuropathies
Christian Krarup University of Copenhagen

Neuroimaging
Federica Agosta Vita-Salute San Raffaele University / IRCCS Ospedale

10:20

Data Analytics
Laith Abu-Nawwas  Centre hospitalier universitaire vaudois
 

  • MIP current and new algorithms
 

Group 4 
Chair: Femke Bouwman Amsterdam University Medical Centers
 
10:30

Coffee Break

Autonomic nervous system disorders
Alexandra Fanciulli Medical University Innsbruck

Headache
Pablo Irimia Universidad de Navarra

Neurosonolgy
David Skoloudik University of Ostrava

Higher & cortical functions
Masud Husain University of Oxford

ALS & frontotemporal dementia
Andrea Calvo University of Turin

10:45

 

Dementia Use Case
Mélanie Leroy Université de Lille

 

  • Selection of metadata and descriptive analyses
  • Developing a predictive model
  • Clustering analyses
10:30 COFFEE BREAK 11:15


TBI Use Case
Stefano Finazzi | Mario Negri Institute for Pharmacological Research IRCCS

 

  • Selection of metadata and descriptive analyses
  • Validation of prognostic models
     
10:45 Report of the four groups
Maurizio Leone, Mara Rocca, Eavan McGovern, Romana Höftberger, Femke Bouwman
11:45 Concluding remarks
Thomas Berger & Philippe Ryvlin
12:15 END OF THE MEETING

Mathew Birdsall Abrams is Head of Science and Training at the International Neuroinformatics Coordinating Facility (INCF), an organization dedicated to developing collaborative neuroinformatics infrastructure and standards, as well as promoting the sharing of data and computing resources to the international research community. For the last 5 years, Mathew has worked with an international group of scientists developing standards, data models, and infrastructure that support neuroimaging, electrophysiology, modeling, and the digital brain atlasing communities. Before joining INCF, Mathew was a researcher in the Department of Neuroscience at Karolinska Institute where his research involved the use of rodent models of traumatic spinal cord injury.

Katrin Amunts did a postdoctoral fellowship at the C. & O. Vogt Institute of Brain Research at Duesseldorf University, Germany. In 1999, she set up a new research unit for Brain Mapping at the Research Center Juelich, Germany. In 2004, she became professor for Structural-Functional Brain Mapping, and in 2008 a full professor at the Department of Psychiatry, Psychotherapy and Psychosomatics at the RWTH Aachen University as well as director of the Institute of Neuroscience and Medicine (INM-1) at the Research Center Juelich. Since 2013, she is a full professor for Brain Research, director of the C. and O. Vogt Institute of Brain Research, Heinrich-Heine University Duesseldorf and director of the Institute of Neuroscience and Medicine (INM-1), Research Center Juelich. Katrin Amunts is a member of the editorial board of Brain Structure and Function. She is member of the German Ethics Council since 2012, and has been elected as vice chair in 2016. Katrin Amunts is the programme speaker of the programme Decoding the Human Brain of the Helmholtz Association, Germany. She is leading Subproject 2 Human Brain Organization of the European Flagship Project The Human Brain Project (HBP). In 2016, she has been elected as Scientific Research Director and Chair of the Science and Infrastructure Board (SIB) of the HBP. Since 2017 Katrin Amunts is co-speaker of the graduate school Max-Planck School of Cognition and since 2018 she is a member of the International Advisory Council Healthy Brains for Healthy Lives, Canada. In order to better understand the organizational principles of the human brain, she and her team aim to develop a multi-level and multi-scale brain atlas, and use methods of high-performance computing to generate ultra-high resolution human brain models.

Jan Bjaalie, M.D., Ph.D., is professor at the Institute of Basic Medical Sciences, University of Oslo, and Infrastructure Operations Director and leader of the Neuroinformatics Platform of the EU Human Brain Project. He was founding Executive Director of the International Neuroinformatics Coordinating Facility (INCF) and is currently head of the INCF Norwegian Node and member of the INCF Council for Training, Science, and Infrastructure. His research group has studied wiring patterns of the brain and developed data systems for organizing and managing heterogeneous neuroscience research data by use of a new generation of digital brain atlases. The group develops software and workflows for analysis of data integrated in the atlases. Jan Bjaalie is Chief editor of Frontiers in Neuroinformatics and Section editor of Brain Structure and Function.

Paul Boon is Senior Full Professor of Neurology and Director of Neuroscience at Ghent University, Belgium. He is also Chair of the Department of Neurology and Chair of the Division of Head, Movement and Senses at Ghent University Hospital Ghent, as well as Professor of Neuromodulation, at Eindhoven University of Technology. As a Board Member and former Chair of the EAN Programme Committee, he has actively contributed to the annual EAN congresses. He has also previously served as Co-Chair of the EAN Scientific Panel on Epilepsy, member of the European Journal of Neurology Editorial Board, and as a member of the EAN Scientific Committee. He is a Fellow of the European Academy of Neurology (FEAN) and EAN President Elect. Prof. Boon’s main neurological interests are clinical epilepsy, neurological sleep disorders, quantitative EEG and MEG analysis, neuromodulation and functional neuroimaging. He founded the 4Brain Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology at Ghent University.

Erika Borcel is a passionate neuroscientist who works at CHUV hospital in Switzerland. She got a PhD. in Neurosciences and after a successful career in academia as a researcher, she decided to move one step beyond the laboratory towards project management in clinical environments. Since 2019, she works as project manager for the HBP’s Medical Informatics Platform and the Human Intracerebral EEG Platform, leading the coordination of the deployment at both operational and administrative levels and being responsible for the legal and ethics affairs.

Dr. Kristian Steen Frederiksen is the co-chair of the EAN Dementia and cognitive disorders scientific panel. Dr. Frederiksen is a neurologist at the Danish Dementia Research Centre and a director of the Trial Unit, and an active scientist within the dementia field.

Parallel Session 1: Dementia | EAN Scientific Panel on Dementia

The number of patients with dementia is estimated to increase given the aging population. This will lead to a number of challenges in the future in terms of diagnosis and care for patients with dementia. To meet these needs such as early diagnsosis and development of prognostic biomarkers, large datasets, such as the federated datasets on dementia. The EAN Dementia and cognitive disorders scientific panel can play an important role as coordinator and connecting panel members who wish to participate in e.g. consortia.

Minos Garofalakis is the Director of the Information Management Systems Institute (IMSI) at the ATHENA Research and Innovation Centre and a Professor of Computer Science at the School of Electrical & Computer Engineering of the Technical University of Crete (TUC), where he also directs the Software Technology and Network Applications Lab (SoftNet). Previously, he was a Principal Research Scientist at Yahoo! Research in Santa Clara, California (2007-2008), and an Adjunct Associate Professor of Computer Science at the University of California, Berkeley (2006-2008). He also held positions as a Senior Researcher at Intel Research Berkeley (2005-2007), and a Member of Technical Staff at Bell Laboratories (1998-2005). He got his PhD in Computer Science from the University of Wisconsin-Madison in 1998. Minos' research interests lie in the broad areas of Big Data analytics and large-scale Machine Learning/Data Mining. His work has resulted in 36 US Patent filings for companies such as Lucent, Yahoo!, and AT&T. GoogleScholar gives over 15000 citations to his work, and an h-index value of 66. Minos is an ACM Fellow (2018, "for contributions to data processing and analytics"), an IEEE Fellow (2017, "for contributions to data streaming analytics"), and a recipient of the TUC Research Excellence Award (2015), the 2009 IEEE ICDE Best Paper Award, the Bell Labs President's Gold Award (2004), and the Bell Labs Teamwork Award (2003).

During his master in Computer Science from University of Florence in 2007 Stefano Gorini worked at CERN in the IT Department collaborating with Alice experiment for his master thesis. He now works at the Swiss National Supercomputing Centre as HPC Operation Group Lead. His Team is in charge of a private Cloud (Openstack based), few HPC Parallel File System (mainly Spectrum Scale based), Backup infrastructure (Spectrum Protect) and the entire Network of the center (Ethernet and Infiniband). In "his previous life" he has been a Computer Scientist with a strong passion on Storage and System administration. Since 2014 he is also part of the board of HPCXXL, an international user group for sites which have large supercomputing and storage installations.

Affiliation: HPC Operation Group Lead, Swiss National Supercomputing Centre (ETHZ-CSCS)

Data safety in FENIX Infrastructure

In this talk the speakers will give a brief introduction of the Fenix Infrastructure and Service Offering, before focusing on Data Safety. The speaker will take the participants through the ETHZ-CSCS offering for EBRAINS and all the HBP Communities highlighting the Infrastructure role in a service implementation in respect of Security. Particular attention will be on showing what tools ETHZ-CSCS provides to a Portal/Service provider such as EBRAINS, MIP/HIP, TVB, NRP amongst others. Finally there will be given a quick glimpse into the future and the role that “multi-tenancy” will play.

Yannis Ioannidis is a Professor at the Department of Informatics and Telecommunications of the National and Kapodistrian University of Athens as well as an Associated Faculty at the “Athena” Research and Innovation Center, where he also served as the President and General Director for 10 years (2011-2021). His research interests include Database and Information Systems, Data Science, Recommender Systems and Personalization, Data Infrastructures, and Human-Computer Interaction, topics on which he has published over 160 articles in leading journals and conferences and also holds three patents. His work is often inspired by and applied to data management and analysis problems that arise in industrial environments or in the context of other scientific fields (Social Sciences and Humanities, Life Sciences, Physical Sciences) and the Arts. He has been the coordinator and legal entity head of OpenAIRE, which implements the European policies on open access to research publications and data. He is the software director of the European Human Brain Project flagship initiative, and a key partner in the governmental flagship initiatives of the National Network on Climate Change and The Hellenic Precision Medicine Network on Cancer. He has also led or is currently leading the creation of new international or spin-off companies. He is an ACM and IEEE Fellow, a member of Academia Europaea, and a recipient of the ACM SIGMOD Contributions Award and several other research and teaching awards. He is also a vice chair of the European Strategy Forum on Research Infrastructures (ESFRI), the Greek delegate to ESFRI and a member of its Executive Board and a member of the strategic management board of the Greek hub of the UN Sustainable Development Solutions Network.

Melanie Leroy is part of the Human Brain Project since 2016. She works at Lille Memory clinic (France) and was involved in the Medical Informatics Platform installation, as well as in the integration of new clinical data. She is an end-user to the MIP Dementia. She conducted a PhD on the “Contribution of real world databases to improving the diagnosis and prognosis of Alzheimer's disease and frontotemporal lobar degeneration”.

MIP hands-on session &  The MIP federation in dementia:

The Medical Informatics Platform (MIP) Dementia had been installed in several memory clinics across Europe allowing them to federate their real-world databases. Research open access databases had also been integrated such as ADNI (Alzheimer’s Dementia Neuroimaging Initiative), reaching a cumulative case load of more than 5'000 patients (major cognitive disorder due to Alzheimer’s disease, other major cognitive disorder, minor cognitive disorder, controls). The statistic and machine learning tools implemented in the MIP allowed researchers to conduct easily federated analyses among Italian memory clinics (Redolfi et al. 2020) and also across borders between the French (Lille), the Swiss (Lausanne) and the Italian (Brescia) datasets.

Dr. Michaela Th. Mayrhofer (female), is a political scientist and historian by training. She was educated in Vienna, Louvain-la-Neuve, Essex and Paris. In 2010, she received her PhD from both the Ecole des Hautes Etudes en Sciences Sociales and the University of Vienna. The thesis was shortlisted by the Austrian Society for Political Science for the ‘best thesis 2010’ young scientist award.  Her academic career led her to various positions and stays at the Centre de Recherche Médecine, Sciences, Santé et Société, the University of Vienna, the Institute of Technology and Society Studies at the Alpen-Adria-Universität Klagenfurt/Vienna/Graz, the Technical University of Vienna, the Fondation Brocher and the Medical University of Graz. She was involved in the coordination of the BBMRI Preparatory Phase (2008-2013) and is experienced in national and international research projects. Recent research Fellowships comprise the Alpen-Adria-Universität Klagenfurt or the University of Newcastle. She was member of the editorial staff of the Austrian Journal of Political Science (2013-2017). Since 2018, she has been leading the Code of Conduct for Health Research initiative, which aims at developing a code along article 40 of the EU GDPR, considering the specific features of processing personal data in health research. Since 2019, she is Head of ELSI Services & Research of BBMRI-ERIC. From February to August 2020, she took on the role as Interim Co-Director General of BBMRI-ERIC. Trained in qualitative methodology and science and technology studies, her current research focus lies on the governance of the life sciences and the ethics of AI.

Giorgos Papanikos is a Principal Researcher at Athena RC, graduate of the Department of Informatics and Telecommunications, with BSc and MSc degree on Technologies of Computer Systems and Applications, from the National and Kapodistrian University of Athens (NKUA). He has been an S/W Engineer with continuous working experience since 2005, participated in multiple projects under NKUA since 2005, CITE since 2007, as a founding member, Athena RC since 2016, and a number of others as a freelancer. During his professional career he has been a member and manager of a number of design and development teams ranging in size and technologies. Currently he holds the position of Chief Technology Officer in CITE.

Parallel Session 8: Federated analytics | The MIP federated analytics

In this session the Medical Informatics Platform (MIP) federated analytics is presented. The current and future analytical tools implemented in the MIP will be detailed along with the constructs, tools, processes, and restrictions that formulate the solution provided. MIP is a platform providing advanced federated analytics for diagnosis and research in clinical neuroscience research. It is targeting clinicians, clinical scientists and clinical data scientists. It is designed to help adopt advanced analytics, explore harmonized medical data of neuroimaging, neurophysiological and medical records as well as research cohort datasets, without transferring original clinical data. It can be perceived as a virtual database that seamlessly presents aggregated data from distributed sources, provides access and analyze imaging and clinical data, securely stored in hospitals, research archives and public databases. It leverages and re-uses decentralized patient data and research cohort datasets, without transferring original data. Integrated statistical analysis tools and machine learning algorithms are exposed over harmonized, federated medical data.

Fabian Prasser is Professor of Medical Informatics at Charité – Universitätsmedizin Berlin and the Berlin Institute of Health where he heads the Medical Informatics Group. His research interests include the design of data sharing infrastructures, big data architectures for translational medicine and related data protection challenges.

Parallel Session 6: Data privacy | Risk-based data anonymization for medical research

The General Data Protection Regulation requires a risk-based approach to data anonymisation. Although a variety of methods for risk-based anonymisation of health data have been proposed in the literature, they are rarely implemented. Indeed, the challenges of robustly anonymising datasets are often underestimated. This talk will first give an overview of important aspects of health data anonymisation. It will then present software tools that can be used to implement them. Finally, concrete anonymisation methodologies involving applications of these tools in real-world health data sharing scenarios will be presented.

Jason Sakellariou is a research associate in the Athena Research and Innovation Center in Athens, Greece. Since 2018 he works on the Medical Informatics Platform (MIP) within the Human Brain Project. Mr. Sakellariou contributes to the development of the analytical tools, machine learning and statistics algorithms, of the MIP. Before that he was for three years a postdoctoral researcher at the Sony Computer Science Lab in Paris, France where he did research on new machine learning algorithms for automatic music composition. Jason Sakellariou received his BSc in fundamental physics from the University of Crete, Greece, my MSc in physics of complex systems from the Université Paris Diderot in France and his PhD in theoretical physics, entitled «Inverse inference in the asymmetric Ising model», from the Université Paris Sud in France.

Parallel Sessin 8: Federated analysis | How to build and validate a federated algorithm

The Medical Informatics Platform (MIP) is a platform providing federated analytics for diagnosis and research in clinical neuroscience research. The federated analytics is possible thanks to a distributed engine that executes computations and transfers information between the members of the federation (hospital nodes). In this talk the speaker will describe the process of designing and implementing new analytical tools, i.e. statistical and machine learning algorithms.  Mr. Sakellariou will further describe the environment in which these federated algorithms run, the challenges and the available tools, the principles that guide its design and the followed general methodology for each new algorithm. One of the most important challenges which are faced is to design these tools in a way that does not compromise the privacy of the clinical data involved. The speaker will show how to address the main questions when designing such algorithms: how to decompose and distribute the computations and what kind of information to exchange between nodes, in order to comply with the privacy constraint mentioned above. Finally, also the subject of validating these federated algorithms will be briefly touched.

In his double-role as Human Brain Project (HBP) Director General and EBRAINS CEO, Paweł Świeboda chairs the Directorate of the HBP, guiding its transition into an enduring, sustainable European research infrastructure, EBRAINS, and heads the EBRAINS AISBL in Brussels, which was established in 2019 as an international non-profit association under Belgian law. Mr Świeboda had served as Deputy Head and Head of Research of the European Political Strategy Centre (EPSC, then IDEA) at the European Commission since 2015. In this capacity, he was co-responsible for the formulation of long-term, strategic advice to the President of the Commission, focusing on economic, research and innovation issues. He has also served on the Commission’s Sounding Board on EU Science, Research and Innovation Performance. Earlier, he was Director of the EU Department at the Polish Ministry of Foreign Affairs from 2001 to 2006, and EU Advisor to the President of Poland from 1996 to 2000. He is an active member of the European and international research community and prolific contributor to the public debate on the future of Europe, emerging technologies, democracy and global governance.

After his PhD in bioinformatics at the University of Birmingham, Alex Upton completed a Marie-Curie postdoctoral position at the Bitlab group at the University of Malaga. His research there involved extensive collaboration with local hospitals, in order to analyse clinical data using computationally intensive methods to identify potential biomarkers of interest. In addition, he was involved in the proposal development and co-ordination of the training areas of the H2020 project Elixir EXCELERATE. After that, he joined ETH Scientific IT Services in 2016 as a Community Project Manager, and was involved in the Swiss national projects EnhanceR, DLCM, and openRDM.swiss. He joined the Swiss National Supercomputing Centre (CSCS) in July 2019, where he works as a Research Project Manager, and is actively involved in the European initiatives PRACE-6IP and the Human Brain Project.

Affiliation: Research Project Manager, Swiss National Supercomputing Centre (ETHZ-CSCS)

Data safety in FENIX Infrastructure

In this talk the speakers will give a brief introduction of the Fenix Infrastructure and Service Offering, before focusing on Data Safety. The speaker will take the participants through the ETHZ-CSCS offering for EBRAINS and all the HBP Communities highlighting the Infrastructure role in a service implementation in respect of Security. Particular attention will be on showing what tools ETHZ-CSCS provides to a Portal/Service provider such as EBRAINS, MIP/HIP, TVB, NRP amongst others. Finally there will be given a quick glimpse into the future and the role that “multi-tenancy” will play.

Maaike van Swieten obtained her PhD in clinical neurosciences from the University of Oxford, where she also helped set up a departmental data sharing platform. She is currently working as a data curation scientist in the EBRAINS Data and Knowledge Team. Using her broad neuroscience background working with human, non-human subjects and computational models, she is giving expert advise on data sharing according to the FAIR guiding principles. Maaike is passionate about advancing open science; she (co-)develops educational training material on data management and data sharing, and is a member of the International Brain Initiative’s Data Sharing and Standards Training Task Force.

Dr von Oertzen trained in neurology and epileptology in Bonn, Germany. He worked as a consultant Neurologist and Epileptologist at the Department of Epileptology, University of Bonn, and at the Atkinson Morley Neuroscience Centre, St. George’s Hospital and University of London, UK, prior to his appointment in Austria. His clinical and research interests are neuroimaging in Epilepsy, comorbidity in Epilepsy and Epilepsy surgery. He has published in various high ranked medical journals, written several book chapters, and is a speaker on national and international meetings. Dr von Oertzen is president of the Austrian Society of Epileptology (ÖGfE, Austrian ILAE Chapter), co-chair of the communication committee of the European Academy of Neurology (EAN), co-chair of the scientific panel for Epilepsy (EAN) as well as president of the Upper Austrian MS Society. He was awarded fellowship of the Royal Collage of Physicians (London) in 2008 as well as the fellowship of the European Academy of Neurology in 2015.

Parallel session 7: Epilepsy | EAN scientific panel on epilepsy

The epilepsy SP actively promotes and supports epilepsy-related issues as well as educational and scientific activities within the framework of EAN. Our partners ILAE/ILAE Europe, EpiCare, EPNS and AOAN are actively involved. One of the major tasks is promoting submissions of session proposals for EAN congress balancing new scientific approaches and educational need for teaching courses. Outside of congress activities, contributions to e-learning facilities on the EAN website such as registrars reading list, scales and scores and breaking news are regularly presented or updated. Particular since the COVID pandemic, publications on COVID and any issues of epilepsy or seizures are regularly screened and summarized in neurology updates. In partnership with the ILAE/ILAE Europe, several guidelines are under preparation.

Scientific Chairs

Prof. Philippe Ryvlin Centre hospitalier universitaire Vaudois, Switzerland

Prof. Thomas Berger | Medical University Vienna, Austria


Contact

workshop.edu@humanbrainproject.eu

 

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IN COOPERATION WITH

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