Work Package 5


EBRAINS Modelling Services

What we do


This Work Package manages the overall architecture integrating scientific software into EBRAINS. It comprises the development and advancement of applications for brain modelling and simulation, analysis of neural activity data, model validation, and visualisation. The deployed services will combine the applications into comprehensive workflows, they will enable multiscale co-simulation of brain processes and closed-loop neuroscience experiments/in silico/, which in turn support R&D on embodied AI and robotics. WP5 delivers the e-infrastructure for operating all services of the Project on the computing infrastructure allocated to them.

How we are organised


WP5 comprises Service Category 3 (SC3) - Brain modelling and simulation workflows: integrated tools to create and investigate models of the brain, SC4 - Closed loop AI and robotics workflows: design, test and implement robotic and AI solutions tasks, and tasks that will deliver the necessary e-infrastructure for all service categories of the Project.



Task T5.1 Molecular and subcellular level description (SC3)
Task T5.2 Detailed cellular level description (SC3)
Task T5.3 Spiking network level description (SC3)
Task T5.4 Whole brain level description (SC3)
Task T5.5 Multi-simulator interaction (SC3)
Task T5.6 Analysis and validation framework (SC3)
Task T5.7 Visualisation framework (SC3)
Task T5.8 Neurorobotics back end (SC4)
Task T5.9 Neurorobotics front end (SC4)
Task T5.10 Neurorobotics closed-loop models (SC4)
Task T5.11 EBRAINS Technical Coordination
Task T5.12 EBRAINS Infrastructure Middleware
Task T5.13 EBRAINS Implementation Management
Task T5.14 EBRAINS Integration, Provisioning and Operations
Task T5.15 WP5 Coordination and Management, including supervision of SC3 and SC4
Task T5.16 The Functional Interplay between Plasticity Processes for Arbor (FIPPA) (SC3)
Task T5.17 Molecular level tools for multiscale simulations (SC3)
Task T5.18 Arbor Implementation of the Inferior Olive Network (ArborIO) (SC3)
Task T5.19 Allosteric modulation of pentameric ligand-gated io channels: relevance to covid 19
Task T5.20 Personalized human musculoskeletal model and exoskeleton coupling with simulated neurorehabilitation
Task T5.21 Closed-loop neurorehabilitation simulator for upper limb
Task T5.22 Blocking SARS-CoV-2-mediated neurodegeneration and brain damage via NLRP3 inflammasome inhibition

Publication highlights


Gaute T. Einevoll, Alain Destexhe, Markus Diesmann, Sonja Grün, Viktor Jirsa, Marc de Kamps, Michele Migliore, Torbjørn V. Ness, Hans E. Plesser, Felix Schürmann, The Scientific Case for Brain Simulations, Neuron, Volume 102, Issue 4, 2019, Pages 735-744, ISSN 0896-6273,

Galindo Sergio E., Toharia Pablo, Robles Oscar D., Pastor Luis, ViSimpl: Multi-View Visual Analysis of Brain Simulation Data, Frontiers in Neuroinformatics, 10, 2016, 10.3389/fninf.2016.00044



Work Package Leader: Yannis Ioannidis

Work Package Manager: Evita Mailli

Webpage editor: wp5(at)