Work Package 1


The human multiscale brain connectome and its variability – from synapses to large-scale networks and function

What we do


This Work Package develops biologically detailed human brain network models capable of generating brain signals as commonly measured in clinical and research settings. By linking a multiscale human brain atlas to computational modelling, the aim is to better understand the fundamental mechanisms of how the brain generates its behaviour. The validity of the principles and concepts is demonstrated in applications to individual patient data for clinical translation such as in epilepsy, and in cohort data to understand human variability such as in healthy aging and pathology. Neuroethical interrogations guide the debate on the role of the digital twin brain in society.

In WP1, components created in the three-year Work Plans of HBP are being assembled to integrate workflows and produce scientific Showcases demonstrating the added value of the integration in EBRAINS. These components involve a battery of tools (bottom-up, top-down) and workflows comprising data, atlases, multiscale models, and simulators. WP1 Showcases are Showcase 1: Degeneracy in neuroscience - when is Big Data big enough? and Showcase 2: Improving epilepsy surgery with the Virtual Big Brain.

In WP1, we use ICT (Information and Communication Technology) simulation science to better understand brain function and improve treatments of the diseased brain. We build personalised brain models based on theories of network science and complex systems and apply these to real-world problems in neuroscience and medicine such as epilepsy and aging. The novel neurotechnologies establish workflows and solutions in EBRAINS, translated to clinics and adopted by industry partners.

How we are organised


To achieve the proposed objectives and produce the Showcases, the WP1 Work Plan is composed of 16 Tasks in which 37 Partners are contributing. These Tasks interact with each other as well as with other Tasks from the science WPs and from the infrastructure WPs. The activities proposed in these Tasks will release 46 Outputs associated to 6 Deliverables.



T1.1 Human brain region-specific molecular and cellular data organisation
T1.3 Nested structural connectomes enriched with region-specific features
T1.4 Human brain functional data collection and organisation
T1.5 Multiscale regional models of human cerebral cortex, hippocampus, cerebellum and basal ganglia
T1.6 Simulation of whole-brain network dynamics and its rhythmic activity, constrained by region-wide differences
T1.7 Integrating population variance and individual predictability into human whole brain network models
T1.8 Data integration and software interface with the multilevel human brain atlas
T1.9 Societal and ethical impact and implications of personalized brain modelling
T1.10 WP1 Coordination, management and WP-related outreach
T1.11 Technical engineering and scientific integration
T1.12 Model-free and model-based inference and validation workflows for causal brain network discovery (NetScovery)
T1.14 Multimodal Whole Brain Imaging in Epilepsy (MOBILE)
T1.15 Whole-bRaIn rodent SpikING neural NETworks (RisingNet) 
T1.16 Dysconnection syndromes and dynamic causal modelling
T1.17 Living Brain dedicated Brain PET in seating/reclined position
T1.18 The role of inflammation and iron in long COVID-19



Work Package Leader: Viktor Jirsa

Work Package Manager: Lisa Otten

Webpage editor: Lisa Otten