The goal of this subproject is to generate strategic data on the structure of the mouse brain, and to facilitate comparisons between mouse brain data and human brain data.

During the Ramp-Up Phase, SP1 focused on genereting data necessary to derive principles of cellular and synaptic organisation and the brain's vascular system. The data generated was uploaded to ther HBP Mouse Brain Atlas. This provides a foundation for the integraiton of community data, and the derivation of general principles of structural organisation essential for the reconstruction of mouse brain models.

This data will be complemented with additional data on ion channels and receptors in the mouse brain, and by work to map mouse genotypes to phenotypes. In SGA1, SP1 aims to work on the following areas:

  • Maps of the vasculature of the whole mouse brain;
  • Whole-brain maps of different cellular types based on gene expression.;
  • Microcircuitry analysis, proteins and receptor distributions, fibre architecture in a specific large brain region;
  • Maps of cellular distributions, long-range axonal projections, and synaptic proteins; reconstructed morphologies of neuron types;
  • Whole-brain activation maps related to selected behaviours;
  • Spatial organisation principles in brain activation;
  • Functional maps of cortical activity during the learning of a motor task after stroke, performed on ther Neurorobotics Platform.

What People are Saying

  • The Strategic Mouse Brain Data Subproject will provide key data on the understanding of the structure of the brain from the molecular to the cellular levels. These data will be used within the HBP to generate atlases that will help understand the organization of the nervous system and will provide quantitative estimates of key parameters for the simulation of brain function.

    Prof. Javier DeFelipe, Cajal Institute, Universidad Politécnica de Madrid,
    co-leader of the Strategic Mouse Brain Data subproject