The goal of this subproject is to generate strategic data to complement and complete existing data on the structure of the mouse brain and to facilitate mouse-human comparisons.

The focus will be on acquiring transcriptome and proteomic data, data on the vasculature, data on cells - the numbers and distributions of excitatory and inhibitory neurons, the morphology of neurons and glia- principles of axonal connections, and synapse maps. During the ramp-up phase, the HBP will focus on generating data necessary to derive principles of cellular and synaptic organisation and the brain's vascular system. The data generated will be uploaded to the HBP Mouse Brain Atlas, providing a foundation for the integration of community data and the derivation of general principles of structural organisation essential for the reconstruction of mouse brain models.

This data will be complemented with additional data on ion channels and receptors in the mouse brain, and by work to map mouse genotypes to phenotypes. This additional work will be the object of two competitive calls:

  1. human and mouse channelomics and receptomics.
  2. genotype to phenotype mapping of the mouse brain.

What People are Saying

  • The Strategic Mouse Brain Data Subproject will provide key data on the understanding of the structure of the brain from the molecular to the cellular levels. These data will be used within the HBP to generate atlases that will help understand the organization of the nervous system and will provide quantitative estimates of key parameters for the simulation of brain function.

    Prof. Javier DeFelipe, Cajal Institute, Universidad Politécnica de Madrid,
    co-leader of the Strategic Mouse Brain Data subproject