Co-Design Project 2

Co-Design Project 2 - 
Mouse-Based Cellular Cortical and Sub-Cortical Microcircuit Models

CDP2 will integrate the activity of HBP platforms in order to refine brain modelling tools through their interactive use open to an enlarged scientific community.

This will happen in two steps, first by exploiting the intrinsic capabilities of HBP teams and then by involving external laboratories as well. CDP2 will build on the experience of the microcircuit model of the somatosensory cortex that has been developed by the EPFL's Blue Brain Project. This requires 3D reconstructions of different morphological types of neurons, with connectivity constrained by published data and facilitated using axonal reconstructions where available. The workflow uses the optimiser framework for the electrophysiological properties of the different neuronal types (e-types). The same strategies and workflows are currently used to develop a draft model of the hippocampal region, which will be used as a benchmark for community development. Similar strategies are currently being investigated for non-cortical regions such as the cerebellum and the basal ganglia. In these cases, model development will first be driven by HBP groups, since the specific features of these brain regions may require adaptations to the general workflow. The transversal SPs activities being performed by this project are highly relevant to the microcircuit models that are being developed, as this modelling work lays the foundation for data-driven modelling of neuromodulation, synaptic plasticity, in silico experimentation, and robotics. This approach also provides a bridge to systems biology and may be instrumental for future HBP drug discovery efforts.

The Products to be developed by CDP2 are as follows:

  • CDP2-P1: Hodgkin-Huxley neuron builder
  • CDP2-P2: Single model benchmark and validation suite
  • CDP2-P3: Community-based modelling strategy on the example of cellular-level hippocampus model
  • CDP2-P4: Cellular-level basal ganglia model: generalisation strategies
  • CDP2-P5: Cellular-level cerebellar model: generalisation strategies and integration in robotic systems
  • CDP2-P6: In silico experimentation lab on the example of the cellular-level neocortical model

CDP Science Leader: Egidio D'ANGELO

CDP Implementation Leader: Michele MIGLIORE